Determination of robust ocular pharmacokinetic parameters in serum and vitreous humor of albino rabbits following systemic administration of ciprofloxacin from sparse data sets by using IT2S, a population pharmacokinetic modeling program.

Robust determination of the concentration-time profile of anti-infective agents in certain specialized compartments is often limited by the inability to obtain more than a single sample from such a site in any one subject. Vitreous humor and cerebrospinal fluid are obvious examples for which the det...

Full description

Saved in:
Bibliographic Details
Main Authors: Drusano, G L, Liu, W, Perkins, R, Madu, A, Madu, C, Mayers, M, Miller, M H
Format: Artigo
Language:Inglês
Published: 1995
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC162807/
https://ncbi.nlm.nih.gov/pubmed/7486900
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items