Pharmacokinetics of Sparfloxacin in the Serum and Vitreous Humor of Rabbits: Physicochemical Properties That Regulate Penetration of Quinolone Antimicrobials

We have used a recently described animal model to characterize the ocular pharmacokinetics of sparfloxacin in vitreous humor of uninfected albino rabbits following systemic administration and direct intraocular injection. The relationships of lipophilicity, protein binding, and molecular weight to t...

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Detalles Bibliográficos

Publicado en:	Antimicrob Agents Chemother
Principais autores:	Liu, Weiguo, Liu, Qing Feng, Perkins, Ruth, Drusano, George, Louie, Arnold, Madu, Assumpta, Mian, Umar, Mayers, Martin, Miller, Michael H.
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 1998
Assuntos:	Pharmacology
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105615/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9624487/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.6.1417
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