Influence of Urinary pH on the Pharmacokinetics of Cinoxacin in Humans and on Antibacterial Activity In Vitro

The impact of acidification and alkalinization of the urine on the pharmacokinetics of cinoxacin was examined after single 500-mg oral doses were administered to nine healthy male volunteers. Acidic and alkaline conditions were achieved by repeated oral doses of ammonium chloride or sodium bicarbona...

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Detalles Bibliográficos

Publicado en:	Antimicrob Agents Chemother
Principais autores:	Barbhaiya, Rashmi H., Gerber, Andreas U., Craig, William A., Welling, Peter G.
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 1982
Assuntos:	Pharmacology
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC181917/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7103450/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.21.3.472
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