Properties of S-adenosyl-L-methionine:macrocin O-methyltransferase in extracts of Streptomyces fradiae strains which produce normal or elevated levels of tylosin and in mutants blocked in specific O-methylations.

An efficient assay for S-adenosyl-L-methionine:macrocin O-methyltransferase, the enzyme which carries out the terminal step in tylosin biosynthesis, is described. Macrocin O-methyltransferase requires Mg2+ and S-adenosyl-L-methionine for activity, has a temperature optimum of about 31 degrees C, and...

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Bibliographic Details
Main Authors: Seno, E T, Baltz, R H
Format: Artigo
Language:Inglês
Published: 1981
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC181703/
https://ncbi.nlm.nih.gov/pubmed/7305323
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