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Competition of beta-lactam antibiotics for the penicillin-binding proteins of Neisseria gonorrhoeae.

The affinities of nine structurally different beta-lactam antibiotics for the three major gonococcal penicillin-binding proteins (PBPs) were determined by using a competition assay with tritium-labeled penicillin and live, growing bacteria. Each determination was carried out in parallel in isogenic...

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Bibliographic Details
Main Authors: Dougherty, T J, Koller, A E, Tomasz, A
Format: Artigo
Language:Inglês
Published: 1981
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC181641/
https://ncbi.nlm.nih.gov/pubmed/6792979
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