Histone hyperacetylation induces demethylation of reelin and 67-kDa glutamic acid decarboxylase promoters

Reelin and glutamic acid decarboxylase 67 (GAD(67)) expression down-regulation in GABAergic interneurons of mice exposed to protracted treatment with l-methionine (MET) is attributed to RELN and GAD(67) promoter cytosine-5-hypermethylation. This process recruits various transcription repressor prote...

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Bibliographic Details
Main Authors: Dong, E., Guidotti, A., Grayson, D. R., Costa, E.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1815468/
https://ncbi.nlm.nih.gov/pubmed/17360583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700529104
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