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A statistical mechanical method to optimize energy functions for protein folding

We present a method for deriving energy functions for protein folding by maximizing the thermodynamic average of the overlap with the native state. The method has been tested by using the pairwise contact approximation of the energy function and generating alternative structures by threading sequenc...

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Hlavní autoři: Bastolla, Ugo, Vendruscolo, Michele, Knapp, Ernst-Walter
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2000
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC18127/
https://ncbi.nlm.nih.gov/pubmed/10760269
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