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Reversal of charge selectivity in transmembrane protein pores by using noncovalent molecular adapters

In this study, the charge selectivity of staphylococcal α-hemolysin (αHL), a bacterial pore-forming toxin, is manipulated by using cyclodextrins as noncovalent molecular adapters. Anion-selective versions of αHL, including the wild-type pore and various mutants, become more anion selective when β-cy...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Gu, Li-Qun, Dalla Serra, Mauro, Vincent, J. Bryan, Vigh, Gyula, Cheley, Stephen, Braha, Orit, Bayley, Hagan
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2000
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC18124/
https://ncbi.nlm.nih.gov/pubmed/10760267
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