Reversal of charge selectivity in transmembrane protein pores by using noncovalent molecular adapters

In this study, the charge selectivity of staphylococcal α-hemolysin (αHL), a bacterial pore-forming toxin, is manipulated by using cyclodextrins as noncovalent molecular adapters. Anion-selective versions of αHL, including the wild-type pore and various mutants, become more anion selective when β-cy...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Gu, Li-Qun, Dalla Serra, Mauro, Vincent, J. Bryan, Vigh, Gyula, Cheley, Stephen, Braha, Orit, Bayley, Hagan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18124/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10760267/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.8.3959
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