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Targeted inhibition of transcription elongation in cells mediated by triplex-forming oligonucleotides

Triple-helix-forming oligonucleotides (TFOs) bind in the major groove of double-stranded DNA at oligopyrimidine⋅oligopurine sequences and therefore are candidate molecules for artificial gene regulation, in vitro and in vivo. We recently have described oligonucleotide analogues containing N3′-P5′ ph...

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I publikationen:Proc Natl Acad Sci U S A
Huvudupphov: Faria, M., Wood, C. D., Perrouault, L., Nelson, J. S., Winter, A., White, M. R. H., Hélène, C., Giovannangeli, C.
Materialtyp: Artigo
Språk:Inglês
Utgiven: National Academy of Sciences 2000
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18107/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10760257/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.8.3862
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