Deficiency of Src homology 2 domain–containing inositol 5-phosphatase 1 affects platelet responses and thrombus growth

Platelets are critical for normal hemostasis. Their deregulation can lead to bleeding or to arterial thrombosis, a primary cause of heart attack and ischemic stroke. Src homology 2 domain–containing inositol 5-phosphatase 1 (SHIP1) is a 5-phosphatase capable of dephosphorylating the phosphatidylinos...

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Autores principales: Séverin, Sonia, Gratacap, Marie-Pierre, Lenain, Nadège, Alvarez, Laetitia, Hollande, Etienne, Penninger, Josef M., Gachet, Christian, Plantavid, Monique, Payrastre, Bernard
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2007
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1810573/
https://ncbi.nlm.nih.gov/pubmed/17347685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29967
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