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Alterations in lipid metabolism gene expression and abnormal lipid accumulation in fibroblast explants from giant axonal neuropathy patients

BACKGROUND: Giant axonal neuropathy (GAN) is a hereditary neurological disorder that affects both central and peripheral nerves. The main pathological hallmark of the disease is abnormal accumulations of intermediate filaments (IFs) in giant axons and other cell types. Mutations in the GAN gene, enc...

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Détails bibliographiques
Auteurs principaux: Leung, Conrad L, Pang, Yinghua, Shu, Chang, Goryunov, Dmitry, Liem, Ronald KH
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2007
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1810559/
https://ncbi.nlm.nih.gov/pubmed/17331252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2156-8-6
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