Atorvastatin interferes with activation of human CD4(+) T cells via inhibition of small guanosine triphosphatase (GTPase) activity and caspase-independent apoptosis

Although a beneficial effect of hydroxy-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, i.e. statins, on cell-mediated immunity has been suggested in vivo and in vitro, little is known about the molecular and biochemical events by which statins inhibit T cell proliferation. To address this...

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Hlavní autoři: Brinkkoetter, P-T, Gottmann, U, Schulte, J, van der Woude, F J, Braun, C, Yard, B A
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2006
Témata:
Basic Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1810423/
https://ncbi.nlm.nih.gov/pubmed/17100774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2006.03217.x
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