Vav1 Dephosphorylation by the Tyrosine Phosphatase SHP-1 as a Mechanism for Inhibition of Cellular Cytotoxicity

Here, we present data suggesting a novel mechanism for regulation of natural killer (NK) cell cytotoxicity through inhibitory receptors. Interaction of activation receptors with their ligands on target cells induces cytotoxicity by NK cells. This activation is under negative control by inhibitory re...

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Bibliographic Details
Main Authors: Stebbins, Christopher C., Watzl, Carsten, Billadeau, Daniel D., Leibson, Paul J., Burshtyn, Deborah N., Long, Eric O.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC180957/
https://ncbi.nlm.nih.gov/pubmed/12917349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.17.6291-6299.2003
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