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Nuclease-Deficient FEN-1 Blocks Rad51/BRCA1-Mediated Repair and Causes Trinucleotide Repeat Instability

Previous studies have shown that expansion-prone repeats form structures that inhibit human flap endonuclease (FEN-1). We report here that faulty processing by FEN-1 initiates repeat instability in mammalian cells. Disease-length CAG tracts in Huntington's disease mice heterozygous for FEN-1 di...

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Hlavní autoři: Spiro, Craig, McMurray, Cynthia T.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2003
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC180932/
https://ncbi.nlm.nih.gov/pubmed/12917330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.17.6063-6074.2003
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