Nuclease-Deficient FEN-1 Blocks Rad51/BRCA1-Mediated Repair and Causes Trinucleotide Repeat Instability

Previous studies have shown that expansion-prone repeats form structures that inhibit human flap endonuclease (FEN-1). We report here that faulty processing by FEN-1 initiates repeat instability in mammalian cells. Disease-length CAG tracts in Huntington's disease mice heterozygous for FEN-1 display...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Spiro, Craig, McMurray, Cynthia T.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2003
Assuntos:	DNA Dynamics and Chromosome Structure
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC180932/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12917330/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.17.6063-6074.2003
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