Nuclease-Deficient FEN-1 Blocks Rad51/BRCA1-Mediated Repair and Causes Trinucleotide Repeat Instability

Previous studies have shown that expansion-prone repeats form structures that inhibit human flap endonuclease (FEN-1). We report here that faulty processing by FEN-1 initiates repeat instability in mammalian cells. Disease-length CAG tracts in Huntington's disease mice heterozygous for FEN-1 display...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Spiro, Craig, McMurray, Cynthia T.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2003
Soggetti:	DNA Dynamics and Chromosome Structure
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC180932/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12917330/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.17.6063-6074.2003
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