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Increased serum C3 levels in Crry transgenic mice partially abrogates its complement inhibitory effects

Complement receptor 1-related gene/protein y (Crry) is a potent murine complement regulator that inhibits C3 convertases. Transgenic mice that overexpress soluble Crry (sCrry), directed systemically by the metallothionein-I promoter, have been used as an animal model for chronic blockade of compleme...

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Detalhes bibliográficos
Main Authors: KANG, H J, BAO, L, XU, Y, QUIGG, R J, GICLAS, P C, HOLERS, V M
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2004
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1809028/
https://ncbi.nlm.nih.gov/pubmed/15086380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2004.02450.x
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