Modulation of antigen presentation by autoreactive B cell clones specific for GAD65 from a type I diabetic patient

We used a GAD65-specific human B–T cell line cognate system in vitro to investigate the modulation of GAD65 presentation by autoantibody, assessed in a proliferation assay. Generally, if the T cell determinant overlaps or resides within the antibody epitope, effects of presentation are blunted while...

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Bibliografiske detaljer
Main Authors: BANGA, J P, MOORE, J K, DUHINDAN, N, MADEC, A M, VAN ENDERT, P M, ORGIAZZI, J, ENDL, J
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2004
Fag:
Basic Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1808922/
https://ncbi.nlm.nih.gov/pubmed/14678267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2004.02343.x
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