PPARα siRNA–Treated Expression Profiles Uncover the Causal Sufficiency Network for Compound-Induced Liver Hypertrophy

Uncovering pathways underlying drug-induced toxicity is a fundamental objective in the field of toxicogenomics. Developing mechanism-based toxicity biomarkers requires the identification of such novel pathways and the order of their sufficiency in causing a phenotypic response. Genome-wide RNA inter...

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Bibliografiske detaljer
Main Authors: Dai, Xudong, Souza, Angus T. De, Dai, Hongyue, Lewis, David L, Lee, Chang-kyu, Spencer, Andy G, Herweijer, Hans, Hagstrom, Jim E, Linsley, Peter S, Bassett, Douglas E, Ulrich, Roger G, He, Yudong D
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2007
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1808491/
https://ncbi.nlm.nih.gov/pubmed/17335344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.0030030
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