Structural analysis of the evolution of steroid specificity in the mineralocorticoid and glucocorticoid receptors

BACKGROUND: The glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) evolved from a common ancestor. Still not completely understood is how specificity for glucocorticoids (e.g. cortisol) and mineralocorticoids (e.g. aldosterone) evolved in these receptors. RESULTS: Our analysis of sever...

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Autori principali: Baker, Michael E, Chandsawangbhuwana, Charlie, Ollikainen, Noah
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2007
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1805736/
https://ncbi.nlm.nih.gov/pubmed/17306029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2148-7-24
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