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Loss of a histone deacetylase dramatically alters the genomic distribution of Spo11p-catalyzed DNA breaks in Saccharomyces cerevisiae

In eukaryotes, meiotic recombination events are distributed nonrandomly in the genome, with certain regions having high levels of recombination (hotspots) and others having low levels (coldspots). Species with similar DNA sequences (for example, chimpanzees and humans) can have strikingly different...

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Autori principali: Mieczkowski, Piotr A., Dominska, Margaret, Buck, Michael J., Lieb, Jason D., Petes, Thomas D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1805699/
https://ncbi.nlm.nih.gov/pubmed/17360459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700412104
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