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An SGK1 site in WNK4 regulates Na(+) channel and K(+) channel activity and has implications for aldosterone signaling and K(+) homeostasis
The steroid hormone aldosterone is secreted both in the setting of intravascular volume depletion and hyperkalemia, raising the question of how the kidney maximizes NaCl reabsorption in the former state while maximizing K(+) secretion in the latter. Mutations in WNK4 cause pseudohypoaldosteronism ty...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1803763/ https://ncbi.nlm.nih.gov/pubmed/17360471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611728104 |
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