WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K(+) channel ROMK1 (Kir1.1)

The serine–threonine kinase WNK3 modulates Cl(−) transport into and out of cells through its regulation of SLC12A cation–Cl(−) cotransporters, implicating it as (one of) the long-sought Cl(−)/volume-sensitive kinase(s). Integrators in homeostatic systems regulate structurally diverse but functionall...

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Detalhes bibliográficos
Main Authors: Leng, Qiang, Kahle, Kristopher T, Rinehart, Jesse, MacGregor, Gordon G, Wilson, Frederick H, Canessa, Cecilia M, Lifton, Richard P, Hebert, Steven C
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2006
Assuntos:
Molecular and Genomic
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1796803/
https://ncbi.nlm.nih.gov/pubmed/16357011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2005.102202
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