Phenotypic reversal of the btn1 defects in yeast by chloroquine: A yeast model for Batten disease

BTN1 of Saccharomyces cerevisiae encodes an ortholog of CLN3, the human Batten disease gene. We have reported previously that deletion of BTN1, btn1-Δ, resulted in a pH-dependent resistance to d-(−)-threo-2-amino-1-[p-nitrophenyl]-1,3-propanediol (ANP). This phenotype was caused by btn1-Δ strains ha...

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Bibliografiske detaljer
Main Authors: Pearce, David A., Carr, Carrie J., Das, Biswadip, Sherman, Fred
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 1999
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC18035/
https://ncbi.nlm.nih.gov/pubmed/10500178
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