The Yeast Model for Batten Disease: Mutations in btn1, btn2, and hsp30 Alter pH Homeostasis

The BTN1 gene product of the yeast Saccharomyces cerevisiae is 39% identical and 59% similar to human CLN3, which is associated with the neurodegenerative disorder Batten disease. Furthermore, btn1-Δ strains have an elevated activity of the plasma membrane H(+)-ATPase due to an abnormally high vacuo...

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Main Authors: Chattopadhyay, Subrata, Muzaffar, Neda E., Sherman, Fred, Pearce, David A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2000
Teme:
Eukaryotic Cells
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC94788/
https://ncbi.nlm.nih.gov/pubmed/11053386
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