Phenotypic reversal of the btn1 defects in yeast by chloroquine: A yeast model for Batten disease
BTN1 of Saccharomyces cerevisiae encodes an ortholog of CLN3, the human Batten disease gene. We have reported previously that deletion of BTN1, btn1-Δ, resulted in a pH-dependent resistance to d-(−)-threo-2-amino-1-[p-nitrophenyl]-1,3-propanediol (ANP). This phenotype was caused by btn1-Δ strains ha...
Guardat en:
| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1999
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18035/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10500178/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.20.11341 |
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