Pharmacokinetic Interaction between Darunavir Boosted with Ritonavir and Omeprazole or Ranitidine in Human Immunodeficiency Virus-Negative Healthy Volunteers

Darunavir (DRV; TMC114; Prezista) is a human immunodeficiency virus (HIV) protease inhibitor used in combination with low-dose ritonavir (RTV) (DRV/r) as a pharmacokinetic enhancer. Protease inhibitor absorption may be decreased during coadministration of drugs that limit stomach acid secretion and...

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Main Authors: Sekar, Vanitha J., Lefebvre, Eric, De Paepe, Els, De Marez, Tine, De Pauw, Martine, Parys, Wim, Hoetelmans, Richard M. W.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2007
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1803132/
https://ncbi.nlm.nih.gov/pubmed/17210768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01203-06
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