Two-Year Assessment of Entecavir Resistance in Lamivudine-Refractory Hepatitis B Virus Patients Reveals Different Clinical Outcomes Depending on the Resistance Substitutions Present

Entecavir (ETV) is a deoxyguanosine analog approved for use for the treatment of chronic infection with wild-type and lamivudine-resistant (LVDr) hepatitis B virus (HBV). In LVD-refractory patients, 1.0 mg ETV suppressed HBV DNA levels to below the level of detection by PCR (<300 copies/ml) in 21...

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Autores principales: Tenney, Daniel J., Rose, Ronald E., Baldick, Carl J., Levine, Steven M., Pokornowski, Kevin A., Walsh, Ann W., Fang, Jie, Yu, Cheng-Fang, Zhang, Sharon, Mazzucco, Charles E., Eggers, Betsy, Hsu, Mayla, Plym, Mary Jane, Poundstone, Patricia, Yang, Joanna, Colonno, Richard J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2007
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1803124/
https://ncbi.nlm.nih.gov/pubmed/17178796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00833-06
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