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Quinoline Derivative MC1626, a Putative GCN5 Histone Acetyltransferase (HAT) Inhibitor, Exhibits HAT-Independent Activity against Toxoplasma gondii

We report that quinoline derivative MC1626, first described as an inhibitor of the histone acetyltransferase (HAT) GCN5, is active against the protozoan parasite Toxoplasma gondii in vitro. However, MC1626 does not inhibit Toxoplasma GCN5 HATs or reduce HAT-mediated activity; rather, this quinoline...

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Detalhes bibliográficos
Main Authors: Smith, Aaron T., Livingston, Meredith R., Mai, Antonello, Filetici, Patrizia, Queener, Sherry F., Sullivan, William J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1803115/
https://ncbi.nlm.nih.gov/pubmed/17178801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01256-06
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