Quinoline Derivative MC1626, a Putative GCN5 Histone Acetyltransferase (HAT) Inhibitor, Exhibits HAT-Independent Activity against Toxoplasma gondii

We report that quinoline derivative MC1626, first described as an inhibitor of the histone acetyltransferase (HAT) GCN5, is active against the protozoan parasite Toxoplasma gondii in vitro. However, MC1626 does not inhibit Toxoplasma GCN5 HATs or reduce HAT-mediated activity; rather, this quinoline...

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Bibliografski detalji
Glavni autori: Smith, Aaron T., Livingston, Meredith R., Mai, Antonello, Filetici, Patrizia, Queener, Sherry F., Sullivan, William J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2007
Teme:
Mechanisms of Action: Physiological Effects
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1803115/
https://ncbi.nlm.nih.gov/pubmed/17178801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01256-06
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