Garcinol Inhibits GCN5-Mediated Lysine Acetyltransferase Activity and Prevents Replication of the Parasite Toxoplasma gondii

Lysine acetylation is a critical posttranslational modification that influences protein activity, stability, and binding properties. The acetylation of histone proteins in particular is a well-characterized feature of gene expression regulation. In the protozoan parasite Toxoplasma gondii, a number...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Autores principales: Jeffers, Victoria, Gao, Hongyu, Checkley, Lisa A., Liu, Yunlong, Ferdig, Michael T., Sullivan, William J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2016
Materias:
Experimental Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4808158/
https://ncbi.nlm.nih.gov/pubmed/26810649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03059-15
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