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Role for Non-Proteolytic Control of M-phase Promoting Factor Activity at M-phase Exit
M-phase Promoting Factor (MPF; the cyclin B-cdk 1 complex) is activated at M-phase onset by removal of inhibitory phosphorylation of cdk1 at thr-14 and tyr-15. At M-phase exit, MPF is destroyed by ubiquitin-dependent cyclin proteolysis. Thus, control of MPF activity via inhibitory phosphorylation is...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1803016/ https://ncbi.nlm.nih.gov/pubmed/17327911 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000247 |
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