Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi

The proteolytic cleavage of sterol regulatory element-binding proteins (SREBPs) is regulated by SREBP cleavage-activating protein (SCAP), which forms complexes with SREBPs in membranes of the endoplasmic reticulum (ER). In sterol-depleted cells, SCAP facilitates cleavage of SREBPs by Site-1 protease...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Nohturfft, Axel, DeBose-Boyd, Russell A., Scheek, Sigrid, Goldstein, Joseph L., Brown, Michael S.
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1999
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18017/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10500160/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.20.11235
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