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De novo amyloid proteins from designed combinatorial libraries

Amyloid deposits are associated with several neurodegenerative diseases, including Alzheimer’s disease and the prion diseases. The amyloid fibrils isolated from these different diseases share similar structural features. However, the protein sequences that assemble into these fibrils differ substant...

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Autors principals: West, Michael W., Wang, Weixun, Patterson, Jennifer, Mancias, Joseph D., Beasley, James R., Hecht, Michael H.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 1999
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC18013/
https://ncbi.nlm.nih.gov/pubmed/10500156
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