Anticipation and Instability of IT-15 (CAG)N Repeats in Parent-Offspring Pairs with Huntington Disease

Huntington disease (HD) is an autosomal dominant degenerative disorder caused by an expanded and unstable trinucleotide repeat (CAG)n in a gene (IT-15) on chromosome 4. HD exhibits genetic anticipation—earlier onset in successive generations within a pedigree. From a population-based clinical sample...

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Bibliographic Details
Main Authors: Ranen, Neal G., Stine, O. Colin, Abbott, Margaret H., Sherr, Meeia, Codori, Ann-Marie, Franz, Mary Louise, Chao, Nientzu I., Chung, Anneke S., Pleasant, Nicole, Callahan, Colleen, Kasch, Laura M., Ghaffari, Manely, Chase, Gary A., Kazazian, Haig H., Brandt, Jason, Folstein, Susan E., Ross, Christopher A.
Format: Artigo
Language:Inglês
Published: 1995
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1801258/
https://ncbi.nlm.nih.gov/pubmed/7668287
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