Anticipation and Instability of IT-15 (CAG)N Repeats in Parent-Offspring Pairs with Huntington Disease

Huntington disease (HD) is an autosomal dominant degenerative disorder caused by an expanded and unstable trinucleotide repeat (CAG)n in a gene (IT-15) on chromosome 4. HD exhibits genetic anticipation—earlier onset in successive generations within a pedigree. From a population-based clinical sample...

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Bibliografiska uppgifter
Huvudupphovsmän: Ranen, Neal G., Stine, O. Colin, Abbott, Margaret H., Sherr, Meeia, Codori, Ann-Marie, Franz, Mary Louise, Chao, Nientzu I., Chung, Anneke S., Pleasant, Nicole, Callahan, Colleen, Kasch, Laura M., Ghaffari, Manely, Chase, Gary A., Kazazian, Haig H., Brandt, Jason, Folstein, Susan E., Ross, Christopher A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1995
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Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1801258/
https://ncbi.nlm.nih.gov/pubmed/7668287
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