Anticipation and Instability of IT-15 (CAG)N Repeats in Parent-Offspring Pairs with Huntington Disease

Huntington disease (HD) is an autosomal dominant degenerative disorder caused by an expanded and unstable trinucleotide repeat (CAG)n in a gene (IT-15) on chromosome 4. HD exhibits genetic anticipation—earlier onset in successive generations within a pedigree. From a population-based clinical sample...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Ranen, Neal G., Stine, O. Colin, Abbott, Margaret H., Sherr, Meeia, Codori, Ann-Marie, Franz, Mary Louise, Chao, Nientzu I., Chung, Anneke S., Pleasant, Nicole, Callahan, Colleen, Kasch, Laura M., Ghaffari, Manely, Chase, Gary A., Kazazian, Haig H., Brandt, Jason, Folstein, Susan E., Ross, Christopher A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 1995
Materias:
Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1801258/
https://ncbi.nlm.nih.gov/pubmed/7668287
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares