Thrombospondin-1 limits ischemic tissue survival by inhibiting nitric oxide–mediated vascular smooth muscle relaxation

The nitric oxide (NO)/cGMP pathway, by relaxing vascular smooth muscle cells, is a major physiologic regulator of tissue perfusion. We now identify thrombospondin-1 as a potent antagonist of NO for regulating F-actin assembly and myosin light chain phosphorylation in vascular smooth muscle cells. Th...

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Hlavní autoři: Isenberg, Jeff S., Hyodo, Fuminori, Matsumoto, Ken-Ichiro, Romeo, Martin J., Abu-Asab, Mones, Tsokos, Maria, Kuppusamy, Periannan, Wink, David A., Krishna, Murali C., Roberts, David D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2007
Témata:
Hemostasis, Thrombosis, and Vascular Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1801044/
https://ncbi.nlm.nih.gov/pubmed/17082319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-08-041368
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