An important base triple anchors the substrate helix recognition surface within the Tetrahymena ribozyme active site

Key to understanding the structural biology of catalytic RNA is determining the underlying networks of interactions that stabilize RNA folding, substrate binding, and catalysis. Here we demonstrate the existence and functional importance of a Hoogsteen base triple (U300⋅A97-U277), which anchors the...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Szewczak, Alexander A., Ortoleva-Donnelly, Lori, Zivarts, Maris V., Oyelere, Adegboyega K., Kazantsev, Alexei V., Strobel, Scott A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18008/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10500151/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.20.11183
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