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PD‐0200347, an α(2)δ ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: a PKCα dependent effect
OBJECTIVE: To explore the in vivo effects of PD‐0200347, an α(2)δ ligand of voltage gated Ca(2+) channels, on cell signalling in osteoarthritic (OA) chondrocytes from an experimental dog model, and examine the effect of PD‐0200347 on the major signalling pathways involved in OA cartilage degradation...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BMJ Group
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1798126/ https://ncbi.nlm.nih.gov/pubmed/16249226 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2005.041855 |
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