PD‐0200347, an α(2)δ ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: a PKCα dependent effect

OBJECTIVE: To explore the in vivo effects of PD‐0200347, an α(2)δ ligand of voltage gated Ca(2+) channels, on cell signalling in osteoarthritic (OA) chondrocytes from an experimental dog model, and examine the effect of PD‐0200347 on the major signalling pathways involved in OA cartilage degradation...

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Detalhes bibliográficos
Main Authors: Boileau, C, Martel‐Pelletier, J, Brunet, J, Schrier, D, Flory, C, Boily, M, Pelletier, J‐P
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2006
Assuntos:
Extended Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1798126/
https://ncbi.nlm.nih.gov/pubmed/16249226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2005.041855
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