Oral treatment with PD-0200347, an α(2)δ ligand, reduces the development of experimental osteoarthritis by inhibiting the chondrocytes metalloproteases and inducible nitric oxide synthase gene expression and synthesis

Antzeko izenburuak

• New strategies for the in vivo regulation of metalloprotease gene expression in osteoarthritis chondrocytes by inflammatory mediators
  nork: Pelletier, JP, et al.
  Argitaratua: (2003)
• PD‐0200347, an α(2)δ ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: a PKCα dependent effect
  nork: Boileau, C, et al.
  Argitaratua: (2006)
• The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis.
  nork: Reboul, P, et al.
  Argitaratua: (1996)
• The expression and regulation of nitric oxide synthase in human osteoarthritis-affected chondrocytes: evidence for up-regulated neuronal nitric oxide synthase
  Argitaratua: (1995)
• Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis
  nork: Tat, Steeve Kwan, et al.
  Argitaratua: (2009)