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Mechanism of Antimalarial Action of the Synthetic Trioxolane RBX11160 (OZ277)
RBX11160 (OZ277) is a fully synthetic peroxidic antimalarial in clinical development. To study the possible mechanisms of action of RBX11160, we have examined its ability to inhibit PfATP6, a sarcoplasmic reticulum calcium ATPase and proposed target for semisynthetic peroxidic artemisinin derivative...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Microbiology
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1797759/ https://ncbi.nlm.nih.gov/pubmed/17145800 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01064-06 |
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