The Relationship between Quinolone Exposures and Resistance Amplification Is Characterized by an Inverted U: a New Paradigm for Optimizing Pharmacodynamics To Counterselect Resistance

We determined the relationship between garenoxacin exposure and quinolone-resistant subpopulations for three bacterial isolates in an in vitro hollow-fiber infection model. An “inverted-U” relationship was identified wherein resistant subpopulations rose initially and then declined with increasing e...

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Autores principales: Tam, Vincent H., Louie, Arnold, Deziel, Mark R., Liu, Weiguo, Drusano, George L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2007
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797751/
https://ncbi.nlm.nih.gov/pubmed/17116679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00334-06
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