Isoniazid Bactericidal Activity and Resistance Emergence: Integrating Pharmacodynamics and Pharmacogenomics To Predict Efficacy in Different Ethnic Populations

Isoniazid, administered as part of combination antituberculosis therapy, is responsible for most of the early bactericidal activity (EBA) of the regimen. However, the emergence of Mycobacterium tuberculosis resistance to isoniazid is a major problem. We examined the relationship between isoniazid ex...

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Bibliografiska uppgifter
Huvudupphovsmän: Gumbo, Tawanda, Louie, Arnold, Liu, Weiguo, Brown, David, Ambrose, Paul G., Bhavnani, Sujata M., Drusano, George L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology (ASM) 2007
Ämnen:
Pharmacology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1913269/
https://ncbi.nlm.nih.gov/pubmed/17438043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00185-07
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