Antibacterial Activity and Mechanism of Action of a Novel Anilinouracil-Fluoroquinolone Hybrid Compound

The anilinouracils (AUs) such as 6-(3-ethyl-4-methylanilino)uracil (EMAU) are a novel class of gram-positive, selective, bactericidal antibacterials which inhibit pol IIIC, the gram-positive-specific replicative DNA polymerase. We have linked various fluoroquinolones (FQs) to the N-3 position of EMA...

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Päätekijät: Butler, Michelle M., LaMarr, William A., Foster, Kimberly A., Barnes, Marjorie H., Skow, Donna J., Lyden, Patrick T., Kustigian, Lauren M., Zhi, Chengxin, Brown, Neal C., Wright, George E., Bowlin, Terry L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2007
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Mechanisms of Action: Physiological Effects
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797695/
https://ncbi.nlm.nih.gov/pubmed/17074800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01311-05
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