Antibacterial Activity and Mechanism of Action of a Novel Anilinouracil-Fluoroquinolone Hybrid Compound

The anilinouracils (AUs) such as 6-(3-ethyl-4-methylanilino)uracil (EMAU) are a novel class of gram-positive, selective, bactericidal antibacterials which inhibit pol IIIC, the gram-positive-specific replicative DNA polymerase. We have linked various fluoroquinolones (FQs) to the N-3 position of EMA...

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Detalhes bibliográficos
Main Authors: Butler, Michelle M., LaMarr, William A., Foster, Kimberly A., Barnes, Marjorie H., Skow, Donna J., Lyden, Patrick T., Kustigian, Lauren M., Zhi, Chengxin, Brown, Neal C., Wright, George E., Bowlin, Terry L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797695/
https://ncbi.nlm.nih.gov/pubmed/17074800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01311-05
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