Antibacterial Activity and Mechanism of Action of a Novel Anilinouracil-Fluoroquinolone Hybrid Compound

The anilinouracils (AUs) such as 6-(3-ethyl-4-methylanilino)uracil (EMAU) are a novel class of gram-positive, selective, bactericidal antibacterials which inhibit pol IIIC, the gram-positive-specific replicative DNA polymerase. We have linked various fluoroquinolones (FQs) to the N-3 position of EMA...

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Autors principals: Butler, Michelle M., LaMarr, William A., Foster, Kimberly A., Barnes, Marjorie H., Skow, Donna J., Lyden, Patrick T., Kustigian, Lauren M., Zhi, Chengxin, Brown, Neal C., Wright, George E., Bowlin, Terry L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2007
Matèries:
Mechanisms of Action: Physiological Effects
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797695/
https://ncbi.nlm.nih.gov/pubmed/17074800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01311-05
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