Low Frequencies of Resistance among Staphylococcus and Enterococcus Species to the Bactericidal DNA Polymerase Inhibitor N(3)-Hydroxybutyl 6-(3′-Ethyl-4′-Methylanilino) Uracil

The 6-anilinouracils (AUs) constitute a new class of bactericidal antibiotics selective against gram-positive (Gr(+)) organisms. The AU family of compounds specifically inhibits a novel target, replicative DNA polymerase Pol IIIC. Like other antibiotics, AUs can be expected to engender the developme...

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Detalhes bibliográficos
Main Authors: Butler, Michelle M., Skow, Donna J., Stephenson, Ryan O., Lyden, Patrick T., LaMarr, William A., Foster, Kimberly A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC132772/
https://ncbi.nlm.nih.gov/pubmed/12435675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.12.3770-3775.2002
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