Overexpression of Akt converts radial growth melanoma to vertical growth melanoma

Melanoma is the cancer with the highest increase in incidence, and transformation of radial growth to vertical growth (i.e., noninvasive to invasive) melanoma is required for invasive disease and metastasis. We have previously shown that p42/p44 MAP kinase is activated in radial growth melanoma, sug...

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Detalhes bibliográficos
Main Authors: Govindarajan, Baskaran, Sligh, James E., Vincent, Bethaney J., Li, Meiling, Canter, Jeffrey A., Nickoloff, Brian J., Rodenburg, Richard J., Smeitink, Jan A., Oberley, Larry, Zhang, Yuping, Slingerland, Joyce, Arnold, Rebecca S., Lambeth, J. David, Cohen, Cynthia, Hilenski, Lu, Griendling, Kathy, Martínez-Diez, Marta, Cuezva, José M., Arbiser, Jack L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797605/
https://ncbi.nlm.nih.gov/pubmed/17318262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30102
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