Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation

Mutations in the human methyl-CpG-binding protein gene MECP2 cause the neurological disorder Rett syndrome and some cases of X-linked mental retardation (XLMR). We report that MeCP2 interacts with ATRX, a SWI2/SNF2 DNA helicase/ATPase that is mutated in ATRX syndrome (α-thalassemia/mental retardatio...

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Detalhes bibliográficos
Main Authors: Nan, Xinsheng, Hou, Jianghui, Maclean, Alan, Nasir, Jamal, Lafuente, Maria Jose, Shu, Xinhua, Kriaucionis, Skirmantas, Bird, Adrian
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1796997/
https://ncbi.nlm.nih.gov/pubmed/17296936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608056104
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