Mxi2 promotes stimulus-independent ERK nuclear translocation

Spatial regulation of ERK1/2 MAP kinases is an essential yet largely unveiled mechanism for ensuring the fidelity and specificity of their signals. Mxi2 is a p38α isoform with the ability to bind ERK1/2. Herein we show that Mxi2 has profound effects on ERK1/2 nucleocytoplasmic distribution, promotin...

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Détails bibliographiques
Auteurs principaux: Casar, Berta, Sanz-Moreno, Victoria, Yazicioglu, Mustafa N, Rodríguez, Javier, Berciano, María T, Lafarga, Miguel, Cobb, Melanie H, Crespo, Piero
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2007
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1794381/
https://ncbi.nlm.nih.gov/pubmed/17255949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601523
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